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desvenlafaxine will increase the degree or outcome of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Watch. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by nearly fifty%; no dosage adjustment desired with desvenlafaxine doses seven consecutive times straight awa